HYALURONIDASE
PROTOCOL

Emergency

1500iu/1ml

Repeat at 30min intervals, max 4 cycles
Re-assess signs (pain/capillary refill)
Refer to A&E if not resolving

Inject volume equal to filler injected
Direct into area of filler and necrosis
Massage and heat

No forearm dermal test patch needed

Revolax Injection
Expert Knowledge

Cosmetic
Revision

1500iu/4ml

Majority of effect seen within 12h
Repeat if necessary (min 48h, ideally 1-2 week intervals)

Inject small volumes (0.1-0.2ml) in centre point of affected area
Use 30G needle or smaller (e.g. FMS)

Test patch: 0.05ml (20u hyaluronidase)
Observe signs (wheal/itching) for 30min

Using higher concentrations but smaller volumes more successfully dissolves filler HA rather than native HA (as opposed to more dilute/higher volume)