HYALURONIDASE
PROTOCOL

Emergency

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1500iu/1ml

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Repeat at 30min intervals, max 4 cycles
Re-assess signs (pain/capillary refill)
Refer to A&E if not resolving

pippet

Inject volume equal to filler injected
Direct into area of filler and necrosis
Massage and heat

arm

No forearm dermal test patch needed

Revolax Injection
Expert Knowledge

Cosmetic
Revision

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1500iu/4ml

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Majority of effect seen within 12h
Repeat if necessary (min 48h, ideally 1-2 week intervals)

pippet

Inject small volumes (0.1-0.2ml) in centre point of affected area
Use 30G needle or smaller (e.g. FMS)

arm

Test patch: 0.05ml (20u hyaluronidase)
Observe signs (wheal/itching) for 30min

Using higher concentrations but smaller volumes more successfully dissolves filler HA rather than native HA (as opposed to more dilute/higher volume)