Hyaluronic acid (HA) has become a cornerstone of modern aesthetic medicine, with its ability to enhance hydration, stimulate tissue repair, and improve overall skin quality. However, not all HA products are created equal.
The molecular weight of HA significantly influences its biological behaviour and therapeutic outcomes. It is the quality of HA (rather than the quantity) that plays the most vital role in clinical outcomes. Seventy Hyal represents a significant advancement in skin biorevitalisation, distinguished by its exceptionally high molecular weight and unique mechanisms of action.
The Molecular Weight Advantage: Why Size Matters
The defining characteristic of Seventy Hyal is its high molecular weight of over 2000 kiloDaltons, positioning it among the highest molecular weight HA products available in the aesthetic market. This molecular size distinction creates fundamental differences in biological behaviour compared to lower molecular weight alternatives.
Anti-Inflammatory Properties
High molecular weight HA demonstrates significant anti-inflammatory effects within tissue. This property is particularly beneficial for patients with inflammatory skin conditions, including acne, rosacea, and eczema. Additionally, the anti-inflammatory nature of high molecular weight HA makes it suitable for treating age-related low-level inflammation commonly seen in menopausal women and individuals with various health conditions.
In contrast, low molecular weight HA tends to be pro-inflammatory, which while sometimes beneficial for stimulating immune responses, may not be ideal for all treatment scenarios.
Enhanced Cellular Binding and Signalling
The mechanism of action for high molecular weight HA centres on its superior ability to bind to CD44 receptors. CD44 is a cell surface glycoprotein whose primary function involves binding to hyaluronic acid. This binding triggers essential signalling pathways responsible for cellular repair, increased cell proliferation, and new cell production.
High molecular weight HA molecules possess thousands of receptor binding sites along their long chain structure, enabling multiple CD44 interactions. This extensive binding capacity translates to more reliable and consistent fibroblast stimulation compared to low molecular weight alternatives, which have fewer binding sites and therefore reduced CD44 interaction potential.
Extended Tissue Residence Time
The large molecular structure of Seventy Hyal provides significant advantages in tissue longevity. While low molecular weight HA products typically remain active for only 7-10 days before degradation by macrophages or loss through capillary walls, high molecular weight HA demonstrates extended tissue residence.
This longevity translates to sustained biostimulatory effects. Clinical protocols reflect this advantage: whereas treatment with low molecular weight products may be required every 7-10 days for four sessions (providing only 5-6 weeks of biostimulation), Seventy Hyal treatments are administered every four weeks for three sessions, providing continuous biostimulation for four weeks post-treatment, resulting in 16 weeks of total biostimulatory activity, with results capable of lasting far beyond.
Pure, Non-Cross-Linked Formulation
Seventy Hyal contains 30mg of pure, non-cross-linked hyaluronic acid per syringe. The absence of cross-linking agents means all 30mg represents free hyaluronic acid, providing immediate hydration effects upon injection. This contrasts with thermally cross-linked products where not all HA is immediately bioavailable.
The pure formulation contributes to the characteristic “Seventy Hyal glow” – the immediate hydration and luminosity patients experience post-treatment.
Biostimulatory Mechanisms
The biostimulatory effects of Seventy Hyal operate through multiple pathways:
- Collagen and Elastin Production: The CD44 binding triggers fibroblast activation, leading to increased production of structural proteins that improve skin density and firmness.
- Tissue Repair: The signalling cascades initiated by HA-CD44 binding promote cellular repair mechanisms, addressing existing skin damage.
- Hydration Enhancement: The high water-binding capacity of HA molecules increases tissue hydration, supporting cellular nutrition and overall skin health.
- Antioxidant Properties: Like other HA formulations, Seventy Hyal provides antioxidant benefits, protecting against oxidative stress.
Clinical Applications and Versatility
The unique properties of Seventy Hyal make it suitable for comprehensive facial and body treatments. Its anti-inflammatory nature and superior biostimulatory capacity make it particularly effective for:
- Perioral rejuvenation, where traditional fillers may appear unnatural.
- Periorbital treatments (with careful patient selection due to the product’s hydrophilic nature).
- Neck and décolletage rejuvenation.
- Scar improvement.
- Treatment of inflammatory skin conditions.
- Overall skin quality enhancement across various body areas.
Safety Profile and Considerations
The safety profile of Seventy Hyal aligns with other injectable HA products, with standard side effects including bruising and minor swelling. Allergic reactions remain extremely rare given the natural presence of HA in human tissue.
While vascular compromise represents a theoretical risk due to the product’s viscosity, the non-cross-linked nature allows for rapid dissolution with minimal hyaluronidase, providing an immediate solution should complications arise.
Conclusion
Seventy Hyal’s high molecular weight formulation represents a significant advancement in biorevitalisation technology. The superior CD44 binding capacity, extended tissue residence time, and anti-inflammatory properties create a product that delivers both immediate hydration benefits and sustained biostimulatory effects. Understanding these mechanisms of action enables practitioners to optimise treatment protocols and achieve consistent, superior clinical outcomes in skin rejuvenation and repair.
Written by Kirsten Wheeler – Nurse Prescriber, Director at Enhance Clinical, & Seventy Hyal Lead Trainer.
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