Polynucleotides: A Complete Guide

Whilst still relatively new within the aesthetics industry, polynucleotides have very much taken over and dominated recent years. As a favourite of many huge celebrities and influencers, clients are constantly asking their aesthetics practitioners about these hugely popular, yet still somewhat unknown, skin-rejuvenating treatments.

Although these treatments are so popular, they are still in their infancy. Meaning that many clinicians and clients still see polynucleotides as somewhat of an unknown. 

That is why we have put together this comprehensive guide on all thing’s polynucleotides. The guide will look at what exactly they are, how they work, their benefits, how long they last, and so much more. 

What Are Polynucleotides? 

In the world of aesthetics, polynucleotides are known as the future of regenerative injectables and are hailed for their ability to rejuvenate and regenerate the skin. More specifically, polynucleotides are natural constituents which are derived from fish DNA. 

These polynucleotide components typically come from either salmon or trout and play a vital role in several functions that can help improve skin rejuvenation. These functions include collagen production and stimulating cellular activity. 

How Polynucleotides Work

There are many ways in which polynucleotides work within the skin to provide the incredible results that they are famed for. The main ways these treatments work are; 

Tissue Repair – As bio-stimulators, these polynucleotides work on a cellular level to repair and improve skin quality from the inside out.

Collagen & Elastin Production – The polynucleotides stimulate fibroblast cells and thus increase the production of both collagen and elastin. This helps to stimulate tissue repair as well as the regeneration and restoration of the skin. 

Anti-Inflammation – They are less likely to cause inflammation on injection than other injectables. 

How Long do Polynucleotides Take to Work? 

When having polynucleotide treatments, clients can expect to see the full results in around three to five weeks. However, this can differ depending on the individual. 

For the best polynucleotide results, clients are recommended to have multiple treatments. Because of this, it can take around 9-12 weeks to complete the treatments and a further three months for full results to be visible.  

How Long do Polynucleotides Last? 

As with how long it takes to see results, the length of time that the polynucleotide benefits last depends on the client’s skin. So, results can vary massively from individual to individual.

However, you should typically be able to see visible results for 6 to 12 months post-treatment. This means that polynucleotides are much longer-lasting than most other aesthetic treatments on the market. 

After this, to maintain full results, clients should look to have a top-up every three to six months.

Where Polynucleotides Are Injected 

Polynucleotide treatments can be injected in a large range of different areas. However, different areas require different quantities of polynucleotides, this is dependent on the size of the area being treated.

Smaller quantities of polynucleotides are perfect for more fragile areas of the face, such as the periorbital. Larger quantities can be used on the wider face and areas of the body, including the neck, hands, and chest.

Benefits of Polynucleotides 

Polynucleotides can boast a huge number of benefits to clients. These benefits include, but are not limited to: 

• Increased collagen production – The increased production of collagen results in improved skin laxity and reduced sagging. 

• Visible reduction in fine lines and wrinkles – Increased collagen and elastin create much firmer skin, helping to see a visible reduction in fine lines and wrinkles.

• More even skin tone and texture – Polynucleotides are bio-stimulators which encourage cells to combat the effects of ageing, resulting in a more even skin tone and texture.

How Many Polynucleotide Treatments Are Needed to See These Benefits?

As with any aesthetic treatment, result timelines can drastically differ depending on the person receiving the treatment. This is because everybody’s skin is completely different. This may also mean that different individuals may need either more or fewer treatments to see the full results. 

However, as a general rule, to get the full polynucleotide results, it is recommended to have three or four polynucleotide treatments spaced 3 to 4 weeks apart. This full treatment course will ensure that clients see the full polynucleotide results. 

Important Polynucleotide Treatment Information 

Below, we will provide very important polynucleotide safety information for both clients and clinics. When doing your research about polynucleotides, it is incredibly important to understand all the information as this will help to ensure that these treatments are as safe as possible. 

You can also take a look at our blog post, which discusses the topic of ‘Are Polynucleotides Safe?’. 

Who Should Not Have Polynucleotide Treatments? 

While the treatments are very safe, there are several contraindications that both clients and clinics should be aware of. Polynucleotides are not recommended for individuals who:

• Have fish allergies – Polynucleotide treatments should not be given to clients with fish allergies. This is because they are derived from fish, which could cause allergic reactions. 

• Are pregnant or breastfeeding – These treatments are not suitable for individuals who are pregnant, breastfeeding, or undergoing IVF treatment. 

• Have active skin conditions – Polynucleotide treatments should not be injected in any area where there is an active skin condition or infection.

Potential Polynucleotide Side Effects

Polynucleotides, as with any aesthetic treatment, do have some potential side effects that clinics and clients should be aware of. While they are not common, everybody reacts differently. The side effects to be aware of are: 

• Swelling – As the procedure is an injectable, there may be some slight swelling to the treatment area. This can be treated and reduced by applying an ice pack to the injection site. 

• Redness – Redness in the area of injection is another potential side effect. If this occurs, it should subside within a few days.

• Bruising – Although the treatment is minimally invasive, there may still be the potential for bruising to occur at the injection site(s).

• Itchiness – Itchiness of the treatment area is another potential side effect. In the event of this, clients should be strongly advised to avoid itching the area.

• Allergic Reactions – As the treatments are derived from fish DNA, individuals who have fish allergies could potentially experience allergic reactions. Because of this, clinics must ensure clients do not have fish allergies in the initial consultation.  

• Lumps – Small temporary lumps around the injection area are another potential side effect. These should subside within 24-72 hours. 

How do Polynucleotides Differ from Other Popular Treatments? 

There are so many different aesthetic treatments on the market. Because of this, these treatments are constantly compared with one another. Below, we will discuss how polynucleotides differ from a range of other treatments.  

How Polynucleotides Differ from Skin Boosters

Whilst polynucleotides and skin boosters are regularly compared to each other due to their similar abilities to restore and rejuvenate the skin, there are many differences. The main difference comes from the time frames of the different treatments.

Skin boosters offer a more short-term and fast-acting hydration and rejuvenation, which offers an instant glow. Whereas polynucleotides are more of a long-term investment in skin restoration. 

While polynucleotides take longer to show results, their results last much longer than skin boosters. In fact, they can last up to 6 months longer. Skin booster’s benefits can be seen for around 6 months. Whereas polynucleotide benefits can be seen for up to 12 months. 

How Polynucleotides Differ from Dermal Fillers 

The only real similarity between polynucleotides and dermal fillers is that they are both injectable treatments. Other than that, the similarities very much stop there. 

One of the biggest differences between the two is, once again, the timeline of these treatments. Dermal fillers give an instant effect and skin plumpness, whereas polynucleotides are more of a long-term investment in your skin health. 

Another clear difference between the two treatments is what the treatments do. Polynucleotide treatments are designed to increase the production of collagen and elastin, whereas dermal fillers are designed to use hyaluronic acid to add volume to the treatment area. 

What Are the Best Polynucleotide Treatments

As polynucleotides are so popular, there are now so many different polynucleotide treatments on the market. Due to the sheer volume, effectively navigating these different treatments and figuring out which is best for your clinic can be difficult. 

Here at Fox Pharma, we are proud to stock all of the industry-leading polynucleotide treatments such as Nucleofill, Plinest, and the Fox Exclusive market leader, Vitaran. 

Vitaran Polynucleotides – A Fox Pharma Exclusive

Vitaran is an industry-leading CE-marked treatment that is created using purified fragments of salmon trout DNA. It is an incredible bio-revitalising skin injectable that has the ability to improve skin tone, texture, and overall appearance. 

Its CE mark means that it has been designed and manufactured to meet stringent safety and environmental standards. So you can rest assured that this incredible cutting-edge aesthetic treatment is both reliable and trustworthy, and therefore perfect to add to your clinic line-up. 

Register with Fox Pharma today or sign in to purchase our exclusive Vitaran polynucleotide treatment.