What Is the Difference Between Polynucleotides and Skin Boosters?

By Erin Murphy

Polynucleotides are the latest treatment at the forefront of innovation in aesthetics. They do share some similarities in benefits to current treatments, though they are distinct from anything currently available. So, what is the difference between polynucleotides and skin boosters? Read on to find out all about Fox Pharma’s latest polynucleotide VITARAN  vs. skin boosters and in further depth about the Next Generation Skin Booster, Seventy Hyal 2000.

What Are Polynucleotides?

Polynucleotides are the next big trend in aesthetic treatments. As a product part of the next generation of regenerative skincare, polynucleotides are long chains of nucleotides that make up DNA and RNA molecules. These injectables contain filtered, ultra-purified, and sterilised DNA fractions which are typically sourced from salmon DNA.

The benefits that this new treatment provides are unprecedented, likely making it a highly sought-after treatment for your clinic. Polynucleotides have a vast range of benefits for clients, ranging from reducing the appearance of wrinkles to treating acne scarring. Their treatment works on a cellular level, providing treatment that penetrates far into the skin.

What Are Skin Boosters?

Skin boosters, such as Seventy Hyal 2000, are a treatment that has long been popular in helping clients to significantly improve the texture of their skin. These are typically made from hyaluronic acid (HA), which is a natural substance found beneath the skin. Hyaluronic acid retains moisture within the skin and as a result, hydrates it when used within skin boosters. This helps to improve the skin’s texture, tone and overall quality.

Polynucleotides vs. Skin Boosters

So, between polynucleotides vs. skin boosters, what exactly is the difference? They are often compared due to their similar effects on skin rejuvenation. Both treatments are capable of rehydrating the skin and restoring a youthful, natural complexion. However, they work in different ways.

The Effects of Polynucleotides vs. Skin Boosters

The differences between polynucleotides such as VITARAN and skin boosters such as Seventy Hyal and Profhilo lie within their method of working. Both are treatments which can provide significant restorative effects to your clients’ skin. However, they work within different time frames. Skin boosters provide an immediately noticeable result, whereas polynucleotide treatment is a longer-term investment into a client’s skin restoration.

If a client is seeking a fast-acting boost of hydration for an instantly visible glow, regular skin booster treatments may be their preference. This can be ideal as a complexion refresher, ideal for quickly apparent results before a client’s event they want to look impressive for.

If they are looking to reduce the appearance of fine lines and are interested in fully embarking on a long-term skin rejuvenation journey to do so, polynucleotides can provide them with the benefits they are looking for.

In providing both treatments, you can diversify the range of treatments available in your clinic, applicable to your client’s unique needs.

The benefits of polynucleotides

Polynucleotides can help to stimulate fibroblast production, which aids in collagen production, restoring tightness to the skin and reducing the appearance of wrinkles. Below are their full extent of effects:

  • Deep tissue repair processes
  • Acne scarring
  • Skin conditions such as rosacea, melasma, and hyperpigmentation
  • Atrophic scarring
  • Deep lines and sunken wrinkles
  • Skin rehydration and rejuvenation
  • Elastosis
  • Facial ageing such as sagging and the formation of fine lines
  • Lumpy scars

These are the full effects of skin boosters, which primarily derive from their ability to restore a youthful appearance to the skin through HA’s hydrating effects:

  • Youthful, radiant appearance
  • Improved skin tone, texture, and firmness
  • Reduced appearance of fine lines and wrinkles
  • Improvements for dry, crepey skin
  • Increased hydration
  • Improved appearance of dark circles
  • Stimulate collagen and elastin production


An essential point of comparison to consider is their longevity. Polynucleotides take longer to show their effects than skin boosters, but these last longer than skin booster results.

With skin boosters, the results of the treatment will be seen almost instantly and can last between 6 to 12 months varying from client to client.

On the other hand, polynucleotides take multiple treatments for their optimum results to appear. A difference in skin quality will appear between 2 to 3 weeks, though it will be at least 3 months before their full effects will be seen. However, this presents its benefits in their results lasting up to 18 months.

Skin Treatments at Fox Pharma

As the home of the latest skin treatments, you can find all of these effective skin treatments and more at Fox Pharma.

Within our polynucleotides range, you’ll discover VITARAN. We’re the exclusive distributor of VITARAN, an injectable polynucleotide treatment that can wholly rejuvenate your clients’ skin. This is the first 100% quality controlled polynucleotide treatment on the market, so is the most dependable variant of this treatment currently available.

This comes in two variants, representing the power of polynucleotides.


  • For dark circles, skin laxity around the eyes and eye bags
  • High concentration of polynucleotides, 20mg per ml
  • Stimulates collagen synthesis at a cellular level
  • The only CE & 100% quality-controlled polynucleotide on the market
  • Reduces inflammation
  • Skin bio-restructuring capabilities
  • Promotes early changes in the skin cycle
  • Prolonged results lasting up to 18 months


  • Skin regeneration, hydration, skin tightening and overall bio-stimulation to improve skin quality
  • For the face, neck and hands
  • High concentration of polynucleotides, 20ml per syringe
  • The only CE & 100% quality-controlled polynucleotide on the market
  • Promotes early changes in the skin cycle
  • Prolonged results lasting up to 18 months

We also stock many skin boosters to rejuvenate your clients’ appearance, including the Next Generation Skin Booster, Seventy Hyal 2000. If you are curious about other Trending 2024 products that are set to be the next most popular treatments, take a look at our exosomes, chemical peels, and health supplements ranges. 

If you would like to find out more about the range of high-quality aesthetic products we have or have any other questions about Fox Pharma, don’t hesitate to contact us today.

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