Hyaluronic acid, is a natural occurring substance, that is found in virtually all of your body’s cells.

Non Cross-linked HA

Non Cross-linked HA

Cross-Linked HA


Hyaluronic acid (or HA) clusters most densely in the skin, where 50% of the body’s HA reserves can be found. However, it is also found in cartilage, connective tissue, and the synovial fluid that lubricates the body’s joints.

HA is highly soluble and can hold water in greater quantities than its own weight.

Its immunological tolerance, ability to assist in the regeneration of collagen, and excellent absorption properties make the HA molecule an excellent candidate for volumising and moisturising the skin.

However, HA in its natural state has a rapid turnover through enzymatic and free radical degradation with a half-life of 24hr in vivo.

Therefore to be considered as a cosmetic treatment, HA must be chemically modified to prevent decomposition. This process transforms HA from a liquid into a gel by crosslinking hyaluronic acid polymer chains to one another. This crosslinking modification allows HA to fill wrinkles and maintain its shape for a longer period of time.

The more links that are generated through the crosslinking reaction, the longer it takes for the skin to break down the cross-linked hyaluronic acid.

About cohesive and non-cohesive hyaluronic acid

HA dermal fillers can be classified into two main groups: cohesive (monophasic) or non-cohesive (Biphasic) depending on the method of development. The cohesive (monophasic) fillers are composed of a single phase of HA, which may be cross-linked once (mondensified) or continuously (polydensified). The Cohesive monodensified filler is characterised by a highly cross-linked smooth gel.

Cohesive polydensified fillers, like those used in REVOLAX, are characterised by regular densities of cross-linked HA zones. This ensures optimal spreading of the gel into surrounding tissue, allowing larger spaces to be filled with denser parts of the gel and finer pericellular tissue spaces to retain low-density gel in a structured yet malleable form.

Premium hyaluronic acid properties in REVOLAX

REVOLAX, The Nation’s Favourite Dermal Filler, uses a monophasic structure of a regular and dense lattice to provide patients with superior results. The properties of the high-quality hyaluronic acid that forms this dermal filler lead it to be one of the most effective and resultantly popular choices for practitioners to use. Buy REVOLAX dermal filler from Fox Pharma and take advantage of the benefits of premium quality HA.

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If you have any further questions about hyaluronic acid or hyaluronic acid properties, or have any other queries relating to Fox Pharma, please do not hesitate to contact us! We are always happy to help.