Polynucleotides have skyrocketed in popularity in recent years, largely down to their endorsement from huge celebrities such as Kim Kardashian and Jennifer Aniston. While they are incredibly popular, they are still relatively new and somewhat unknown within the aesthetics industry.
Because of this, understandably, there are several questions that practitioners have regarding this somewhat unique form of treatment. In this article, we will look at and answer all the most common questions and queries that we get regarding polynucleotide treatments.
General Polynucleotide Questions
What Are Polynucleotides?
Polynucleotides are minimally invasive aesthetic injectables designed to rejuvenate the complexion. They are derived from fish DNA, which mimics human DNA and works as bio-stimulators to boost fibroblast cells in the skin. This stimulates the production of collagen and elastin which improves skin texture and firmness.
Where Do Polynucleotides Come From?
Polynucleotides, often referred to as salmon sperm facials, utilise the transformative benefits of salmon or trout DNA. The DNA is first extracted from the testes and then distilled and purified before being incorporated into an injectable gel formula.
One of the most commonly asked questions is whether polynucleotides really come from fish sperm. While the DNA is extracted from fish reproductive glands, there is no pure fish sperm in polynucleotides.
Checkout our blog on How to Utilise DNA For Enhanced Skin Rejuvenation
Are Polynucleotides Safe?
Put simply, yes, polynucleotides are safe for most people. Many studies have shown that they are biocompatible and well-tolerated by the body. They are also biodegradable, meaning that the body absorbs them over time reducing the risk of long-term negative effects.
As with most cosmetic treatments, there are associated side effects which include swelling and bruising. However, these are common with most injectables and typically subside within a few days.
Serious side effects, such as allergic reactions, are rare. However, as polynucleotides are formulated with fish DNA, they are not suitable for fish allergy sufferers.
It’s always important to assess your client’s suitability and to carry out a thorough pre-treatment consultation.
Do Polynucleotides Work?
As bio-stimulators, polynucleotides work on a cellular level to repair and improve the quality of the skin from the inside out. They boost fibroblast cells, which increases the production of collagen and elastin, stimulating tissue repair and the regeneration and restoration of the skin. They also have antioxidant and hydrating properties, which help to make the skin look and feel healthier.
Polynucleotide Treatment Questions
Here at Fox Pharma, we also get a huge number of questions regarding polynucleotide treatments. Below, we have answered the most common questions we get.
Alternatively, you can check out our Polynucleotide Treatment Guide to explore everything you need to know.
How Long Do Polynucleotide Injections Last?
After receiving a polynucleotide treatment, clients may notice improvements in their skin within two to three weeks. However, it may take up to three months to see the full effect. The effects of polynucleotide injections generally last for six to 12 months, and clients should schedule maintenance treatments every three to six months to maintain the best results.
Who Are Polynucleotides For? & What Do They Treat?
Polynucleotides are a fantastic treatment option for clients with mature skin looking to reverse visible signs of ageing or as a preventative measure in younger clients. This is because they can effectively treat fine lines and wrinkles, dryness, texture, rosacea, hyperpigmentation, dark circles, scarring, inflammation, and loss of elasticity.
Polynucleotides are generally considered hypoallergenic and suitable for all skin types, including sensitive skin. However, as they derive from fish DNA, they are not appropriate for fish allergy sufferers, vegans, or vegetarians.
Like most cosmetic treatments, polynucleotide injections are not suitable for clients who are under 18, pregnant, trying to conceive, or breastfeeding.
How Many Polynucleotide Treatments Do You Need?
The amount of polynucleotide treatments a client needs depends on their skin, concerns, and goals. To achieve the full desired results of polynucleotide injections, it’s recommended to have two to three sessions, two to four weeks apart.
Polynucleotide Vs Other Treatment Questions
With so many different aesthetic treatments on the market, it is only natural to compare polynucleotides to other well-known treatments. Below, we have answered all the most common questions that we get relating to polynucleotides and other treatments.
Are Polynucleotides Better Than Dermal Fillers?
Polynucleotides and dermal fillers, though both injectables serve different purposes. Polynucleotide injections improve the quality and texture of ageing skin by boosting the production of collagen and elastin.
Dermal fillers are made with hyaluronic acid (HA) and add volume to the skin to plump, sculpt, contour, and shape the face. Whether one is better than the other depends on your client’s skin concerns and goals.
Polynucleotides and dermal fillers can be used in conjunction with one another to help clients achieve their desired look, as long as they are not injected into the same area at the same time.
What’s the Difference Between Polynucleotides and Skin Boosters?
Whilst both polynucleotides and skin boosters work to improve the appearance and quality of ageing skin, they work differently and produce different results. Skin boosters such as Seventy Hyal 2000 use hyaluronic acid (HA) to improve skin hydration and texture.
Also, they have a subtle plumping effect and show almost immediate results, which last up to six months. Polynucleotides also improve skin texture, quality, and firmness as a result of cellular-level repair. Full results tend to take a few weeks to appear and can last up to 12 months.
Polynucleotides and skin boosters can also be used in conjunction with each other to provide the skin with both rejuvenation and hydration for a more youthful appearance.
Want to find out more? Check out our blog which looks in more detail at the differences between polynucleotides and skin boosters.
VITARAN: A Fox Pharma Exclusive

Fox Pharma is home to the latest innovations from the aesthetics industry, including VITARAN, our exclusive polynucleotide range. VITARAN is derived from highly filtered, ultra-purified, sterilised fragments of trout DNA to repair and rejuvenate the skin at a cellular level, offering clients totally transformative results. Additionally, VITARAN is CE-marked to uphold the highest quality and safety standards for your clients.
Qualified practitioners can buy VITARAN online at Fox Pharma.
Register With Fox Pharma
For practitioners wanting to provide polynucleotide injectables to their clients, browse our collection of polynucleotides to see our wide range of products. At Fox Pharma, we’re home to cutting-edge aesthetic products, including dermal fillers, skin boosters, PLLA stimulators, and many more aesthetics supplies.
If you’d like to find out more about polynucleotides and treatment guides for our other products, take a look at the Fox Pharma blog. If you have any more questions, don’t hesitate to contact us today.
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