Timolol 0.5% Eye Drops (1 x 5ml)

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A prescription only medicine Timolol is a beta-adrenoceptor blocking agent used topically in the reduction of elevated intra-ocular pressure in various conditions including following:

- Patients with ocular hypertension.

- Patients with chronic open-angle glaucoma including aphakic patients.

- Some patients with secondary glaucoma.

Special warnings and precautions for use:

See EMC link below for the complete list of special warnings and precautions for use.

EMC: https://www.medicines.org.uk/emc/product/4053/smpc#about-medicine

Patient Information Leaflet: https://www.medicines.org.uk/emc/files/pil.4053.pdf

 

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Description

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Description

Mechanism of action

Timolol maleate is a non-selective beta-adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anaesthetic activity. Timolol maleate combines reversibly with the beta-adrenergic receptor, and this inhibits the usual biologic response that would occur with stimulation of that receptor. This specific competitive antagonism blocks stimulation of the beta-adrenergic stimulating (agonist) activity, whether these originate from an endogenous or exogenous source.

Contraindications:

 - Cardiogenic shock.

- Overt cardiac failure.

- Second and third degree atrioventricular block not controlled with pacemaker.

- Sinus bradycardia, sick sinus syndrome sino-atrial block.

- Reactive airway disease including bronchial asthma or a history of bronchial asthma.

- Presence or history of severe chronic obstructive pulmonary disease.

- Hypersensitivity to the active substance or to any of the excipients or other beta-blocking agents.

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